To get this achievement, you need to have 5 timed buffs active at one time. These are temporary boosts to the stats of your character, and debuffs do not count. Simply drink five different potions at the same by putting them in your top row and hitting cn_RT. They are commonly found in treasure chests all over the world, or they can be crafted. You can craft potions at the Alchemy Station or Flasks at the Imbuing Station. If going for this from the beginning, simply explore the world and save your potions at your home base (or in a piggy bank or safe) until you have five different ones listed below.
LIST OF BUFF POTIONS
Archery Potion
Battle Potion
Featherfall Potion
Gills Potion
Gravitation Potion
Hunter Potion
Ironskin Potion
Magic Power Potion
Mana Regeneration Potion
Night Owl Potion
Obsidian Skin Potion
Regeneration Potion
Shine Potion
Spelunker Potion
Swiftness Potion
Thorns Potion
Water Walking Potion
FLASKS these count as well, but you can only have one active at a time:
Flask of Cursed Flames
Flask of Gold
Flask of Ichor
Flask of Nanites
Flask of Party
Flask of Poison
Flask of Venom
NOTE: Healing potions do not count for this achievement since they cause "Potion Sickness", which is a debuff. Also pets, campfires, and Heart Lanterns do not count as they are not timed buffs for a character.