This trophy, as well as the following trophies, can be obtained all at once:
At the beginning of Act II, once you are running around as Spidey 2099, you will find yourself in an area with DNA Carts you need to protect from very slow, and weak, enemies.
There are 4 carts total, and 3 of them exist in (somewhat) puzzle areas. Get all 4 carts into the center hub, and a bunch of these guys will spawn for a set period of time.
Below is a link by IReflexL2, and he gives some good advice at the end (Purchasing Pain Tornado). Personally, I had no problems spamming my decoy and using Roundhouse Spin to maximize my combo, but his approach works just as well.
Questions, corrections and neg vote justifications in the comments field below.