To get this trophy you have to upgrade all of your weapons and equipment you get during your playthrough using red orbs, which you can do in the Pause Menu. You get red orbs by defeating enemies, destroying objects (like pots) and from red chests and special chests if you fully upgrade your health, magic and/or item bar. Below are the weapons and equipment you need to upgrade and how many red orbs you need:
Blades of Exile
Level 2: 4,000 red orbs
Level 3: 7,000 red orbs
Level 4: 8,000 red orbs
Level 5: 10,000 red orbs
Total: 29,000 red orbs
Bow of Apollo
Level 2: 2,500 red orbs
Claws of Hades
Level 2: 3,000 red orbs
Level 3: 5,000 red orbs
Level 4: 6,000 red orbs
Level 5: 9,000 red orbs
Total: 23,000 red orbs
Head of Helios
Level 2: 2,500 red orbs
Boots of Hermes
Level 2: 2,500 red orbs
Nemean Cestus
Level 2: 3,000 red orbs
Level 3: 5,000 red orbs
Level 4: 5,000 red orbs
Level 5: 8,000 red orbs
Total: 21,000 red orbs
Nemesis Whip
Level 2: 3,000 red orbs
Level 3: 5,000 red orbs
Level 4: 5,000 red orbs
Level 5: 8,000 red orbs
Total: 21,000 red orbs
Total orbs needed: 101,500 red orbs