Start up a quick play game on Rookie difficulty. Play as the New York Jets and you can play against any team you wish. The Jets have two outstanding cornerbacks in Darrelle Revis and Antonio Cromartie. They are ball hawks and will most likely get most of the 5 interceptions you need. Of course, any of your defensive players can intercept the ball to count towards this trophy.
To make this somewhat easier, every time you end up getting the ball, just punt back to the other team. That will give you more chances to snag an interception.
This trophy will pop at the end of the game!