Spoiler alert. If you don't want to know about the spoiler, the best I can say is that you will need to do at least half of a new game+ to get this.
*** Spoiler - click to reveal ***You get ~80% of the pills for Abby and Ellie in the first play through. Chapter select doesn't work, so you will need to play through at least half of a new game+, just to finish off Abby's pill habbit. I got this at the end of Day 1 for Abby. Had Ellies maxed out by middle of day 2, but still had to play rest of her campaign.
1900 pills in total across 10 skill trees, each tree having 5 skills.