To unlock the Where the Red Orbs Grow trophy in Devil May Cry 5, you will need to find the hidden Red Orbs during the game's second mission.
You can find the Red Orbs in DMC5's second level shortly after the start when you fight off some enemies. Ahead of you, the path will split into two. Take the path on the right, fight off some demons that spawn, and then on the right, look for a hole in one of the buildings with a platform underneath it.
Jump up onto the platform, go through the hole in the wall and destroy the orbs to unlock the trophy.