Unlocked only after you complete all of the Screwball challenges. Miles will report on where Screwball's "Wrap Up Party" is being held.
Once you reach the Wrap Party, Screwball will bust out of a box and begin to run. This is a bit of a frantic chase as you'll have to complete each Photobomb challenge during the chase which includes throwing bombs and having to slingshot yourself through the water towers. It can be frustrating to do so, but keep at it. Screwball will eventually launch drones which will put up energy barriers for you to move around. Take the drones out as you get close with
. Once the drones have been eliminated, you can finally catch her.