-( Story related, cannot be missed )-
Upon creating your character, you will need to follow the Overseer's instructions through the tutorial, gearing yourself up for the world outside. You'll meet other Mr. Handy characters at each tutorial workshop before you pick up your PipBoy and leave the vault. Be sure to look everywhere and loot everything you can, as once you leave the Vault, you won't be able to return at all. Primarily, look at every table you come across and make sure to take almost everything on them, especially Perk Cards, ammo, and weaponry.