After about the 3rd or 4th main storyline mission, you are tasked with investigating a Wilson Fisk construction site, which turns out will be one of his base of operations.
There will be at least 1 of these in each district.
This trophy relates to completing the main objective for the bases mission which seems to be just fighting off hordes of people, and some other optional objectives, for me it was doing a 10 hit combo and Performing 10 finishers.
If you finish the base and only accomplish one of the optional objectives, you can replay the base mission and only go focus on the other optional objectives.