In order to unlock the "A Bit of a Fixer Upper" trophy in Marvel's Spider-Man, you must finish every puzzle in Octavius' lab. The lab is available very early in the game (immediately after your first interactions with Octavius) but the full list of puzzles will not be unlocked until after the "Strong Connections" mission in Act 2. You can skip all puzzles and still get the trophy -- just activate the option in the Settings > Accessibility menu (pause the game to access it) which says "Option to Skip Puzzles". Switch that to "ON" and then manually skip each puzzle in the lists with . You still will need to wait until the full lists are unlocked before you can unlock the trophy.FaustusPHD notes that it is possible to skip puzzles without toggling the above Setting, but you will not get the trophy if you do not change the Setting which allows for skipping puzzles. So make sure that you head into the Settings as described above.
Below are all of the solutions if you decide you want to finish them but get stuck on a particular one.
Spectrograph Puzzles (approach the microscope looking object in front of the screen, on the far left table in the lab):L37X23B62V13C06V77S12R80X09P12
Circuitry Puzzles (a table opposite the exit door has a datapad on it, access it to get to the puzzles):Actuator PrecisionMinimal Grip ForceSpatial MappingBalance CompensationPower EfficiencyMicrocable CalibrationMachine Learning SubsystemStage 1 Intercranial InterfaceStage 2 Intercranial InterfacePrecision Targeting
If you have any trouble unlocking the trophy after completing both lists, re-open both puzzle lists and eventually the trophy should trigger.
Check out an excellent video from Thomas' Trophy Tutorials
if you need visual assistance -- all credit to Thomas for the video.