This is story related and cannot be missed. Will pop afterwards in the cutscene.
Stage 1 Turrets – Just spam dodge until the opportunity arises to web them up.
Stage 2 Fisk Fight – You have to use your web shooters to tie him up, once this occurs you can get off 3 to 4 hits but then you need to start dodging because he will start to attack again.
Stage 3 Fisk with Guards – Don’t be afraid to spam dodge and slowly attack the guards. It may take extra time but it’s the safe route. Work by eliminating the guards 1 by 1 and get it down to just you and Fisk. Once this occurs just spam dodge until you get a chance to web him up and hit him with 3 or 4 shots. Rinse and repeat this until the cinematic starts. Once the cinematic starts it will give you the correct button commands to finish the boss fight.
Be on the look out for Fisk hurling objects at you and charging you as well as fire that you don’t wont to walk into.