-( Story related, cannot be missed )-
In Whitechapel, your goal is to locate the person blackmailing Pembroke Hospital. As it turns out, and it will be of no surprise to you since you clicked on this trophy, that it is Nurse Dorothy, posing as Dorothea to aid people that cannot afford the hospital. You have three choices when you finally make it to her audience: Spare, Charm, and Embrace. Be aware of the following trophy as you proceed:
The Hidden Trophy trophy in Vampyr worth 219 pointsContinue playing to unlock this hidden trophy
Embracing Dorothy will null that trophy for this run of the game. However, should you choose to Spare or even Charm her, this will let her live (albeit briefly). The trophy will pop after you have made your choice, so choose wisely.