This battle can be annoying, but is not terribly difficult. George will return (the guy who ate his harmonica) and will this time, be a beast creature.... with a horse. The horse will ride around the fountain and eventually fart out a glob of darkness (gross). Stand in it and when George rides by, shoot him in the back. Keep doing this until the horse falls over, which will allow you to then shoot the horses stomach (and the human blood sack thing). After the horse recovers, it will jump atop the fountain, you can get a few good shoot in again, but be ready to dodge George's lances (TIP: X + Left or Right work great).
Once the horse is dead, George does the only thing one can do when his best friend (presumably) is dead, eat his heart. This will make him into a giant with various weak points.
- One on each ankle (one is an orb, the other a bracelet)
- Three on his back
- One on the back of each ankle
- One on each arm
He'll try to crush the player if you get to close, so it's best to run past him and get a safe distance before shooting at the orbs.
Once all of the orbs have been broken, you'll.... well, darkness happens and there will be no goats. Quickly kill the tapeworm things that burst from his stomach (ignoring the ones on the ground) and you'll win the battle.