This trophy goes hand in hand with the Supplier trophy - as you will need most of the crafting resources to make the items. Runes and Poisons & Grenades are the easiest way to get this trophy, as you will have most of the items to make all of them by the end of the game. The potions tree is harder because if you are anything like me, you've lost Isabela by the end of Act 2; thus destroying your chance of getting that final crafting resource.
You can create potions, runes, and poisons & grenades at the workstation at your home/Gamlens or at various places around the city; Potions - Lady Elegant [Lowtown], Runes - Worthy [Hightown], Poisons & Grenades - Tomwise [Darktown].
All potions, runes, and poisons & grenades have a small fee upon making. Each fee is different per item.
Potions:
Elfroot Potion [gift from Lady Elegant] 1 elfroot
Restoration Potion [sold by Formari Herbalist, Gallows Courtyard; Acts 1-3] 3 elfroot, 2 spindleweed
Elixir of Purity [sold at Emporiums crafting materials, DLC] 3 elfroot, 1 spindleweed
Life Ward Potion [sold by Formari Herbalist, Gallows Courtyard; Acts 2 & 3] 4 elfroot, 3 spindleweed
Rock Armor Potion [looted from rubble beside Gamlens' House, night; Act 2] 2 elfroot, 3 spindleweed, 1 Embrium
Mighty Offense Potion [looted from bones on Sundermount on hidden passage after cemetary; Act 2] 3 elfroot, 2 spindleweed, 1 embrium
Elixir of Heroism Potion [looted from corpse in Hightown during Demands of the Qun] 5 elfroot, 4 spindleweed, 4 embrium, 1 ambrosia
Runes:
Rune of Impact [looted at Wilmod's Camp during Enemies Among Us; Act 1] 1 lyrium
Rune of Fire [looted in the Dark Foundry during The First Sacrifice; Act 1] 2 silverite
Rune of Frost [sold at Lirene's Ferelden Imports, Lowtown] 1 lyrium, 2 silverite
Rune of Lightning [looted in a chest at the Blooming Rose or at the top of Sundermount in a pile of bones; Act 1] 2 lyrium, 3 silverite
Rune of Nature [sold at Master Ilen's Shop, Dalish Camp; Act 2 & 3] 3 lyrium, 3 silverite, 1 orichalcum
Rune of Spirit [looted from a crate in Brekkers Hideaway during the Inside Job; Act 2] 2 lyrium, 3 silverite, 1 orichalcum
Rune of Striking [looted in the DuPuis' Estate during Prime Suspect; Act 2] 4 lyrium, 3 silverite, 2 orichalcum
Rune of Devastation [looted from a chest in the sewer passage when looking for Evelina during On the Loose] 3 lyrium, 4 silverite, 4 orichalcum, 1 dragon's blood
Rune of Protection [gift from Worthy] 1 lyrium
Rune of Fire Warding [looted from a pile of bones on the Wounded Coast; Act 1] 2 lyrium
Rune of Frost Warding [looted from a crate in the Sanctuary during Enemies Among Us; Act 1] 2 lyrium, 1 silverite
Rune of Lightning Warding [sold at Mage Goods, Gallows; Acts 1-3] 3 lyrium, 2 silverite
Rune of Nature Warding [looted from a chest in the Smugglers Cut during the Blackpowder Courtesy] 4 lyrium, 2 silverite
Rune of Spirit Warding [sold at Mage Goods, Gallows; Act 2 & 3] 3 lyrium, 2 silverite, 1 orichalcum
Rune of Defense [looted from a bone pile in Act 2/3] 3 lyrium, 3 silverite, 2 orichalcum
Rune of Valiance [looted in the ruins of the hut near the Vartarrel's lair on Sundermount; Act 3] 6 lyrium, 3 silverite, 3 orichalcum, 1 dragon's blood
Rune of Fortune [Emporium's Crafting Materials, DLC] 2 lyrium, 2 silverite
Poisons & Grenades:
Debilitating Poison [gift from Tomwise] 1 deep mushroom
Tar Bomb [sold at Shady Merchandise, docks; Act 1] 1 deep mushroom, 1 deathroot
Deathroot Toxin [sold at Shady Merchandise, docks; Acts 1-3] 2 deathroot
Crow Venom [sold at Emporiums Crafting Materials, DLC] 2 deep mushrooms, 2 deathroot
Combustion Grenade [looted from the Tal-Vashoth Leader during the Blackpowder Promise] 2 deep mushroom
Mythal's Favor [looted from a wooden crate on the Wounded Coast; Act 2] 2 glitterdust
Arcane Poison [looted from an Elven Fanatic during the Blackpowder Courtesy; Act 2] 2 deep mushroom, 2 deathroot, 1 glitterdust
Fell Poison [loot from Huon during On the Loose; Act 3] 6 deep mushroom, 5 deathroot, 1 felandaris
Fell Grenade [loot from crate on the Wounded Coast; Act 3] 4 deathroot, 4 glitterdust, 1 felandaris