All right people, let's do this.
Just got this one, so here's how I fared.
1. In the convenience store, do NOTHING. The mugger will shoot the storekeeper. So that's one witness down.
2. Keep a close eye on everything that everyone touches in Manfred's shop. It's always going to be the music box, the door, the whiskey glasses, both phones and the magnifying glass. But you might do things differently. So just pay attention.
3. Jayden died for me in Pacos office. I'm not sure if just dying works, because it clearly says "KILL Jayden" So, I just didn't fight back in that fight.
4. Scott went straight for escaping and didn't try to free Lauren. Cold, I know, but she was an Origami witness.
5. Don't give Kramer his pills. Simple as that.
6. Now, Madison, i just didn't put out the fire when her pants caught fire. As such, she died writhing and screaming on Origami's bed. Again, the trophy description says Kill Madison, so I don't know if Dr Baker would count.
And lastly, I completely 3 trials, got the correct address and never had Ethan arrested. As such, he managed to save Shaun and then was shot by police snipers.
That's just what got me the trophy, though. You could theoretically have Jayden die at the end, or have Madison caught in the explosion. Not sure of the effect of Ethan in gaol (jail) though...