You'll encounter the Brute in Chapter 7 (and it's the only one in the game, thank god). In all honesty it's a fairly easy fight if you know what you're doing. When the Brute is charging you, when it gets to about a pillars distance away from you Stasis it and Karen will automatically run to get a better shot at its back, which you'll wanna shoot as much as you can. Repeat this process until the game prompts you to shoot his arm (and then do so), and then the Brute will limp toward you with its one remaining arm pathetically, and will periodically shoot organic bombs at you. Grab these bombs with Kinesis and throw them back at him a few times and you'll have defeated him, thus getting this trophy as well.
Good Luck!