The Guts Of Helios trophy in Borderlands: The Pre-Sequel is story-related and can't be missed.
You will unlock the trophy after completing the game's 10th story mission "Watch Your Step".
*** Spoiler - click to reveal ***- Access tunnels to Veins of Helios
- Traverse Veins of Helios
- Exit airlock
- Enter Central Maintenance
- Breach Lost Legion defences
- Destroy regulators on plasma booster A: 0 / 3
- Destroy regulators on plasma booster B: 0 / 3
- Get to safe distance
- Enter command station
- Find FIX Loader and activate GUN Loader program
- Activate fast travel
- Activate remote shutdown sequence