| Name | Description | |
| Clean Bill O'Health | Collect every Trophy in Two Point Hospital |  |
| Give a Man a Hospital... | Cure 1 Patient |  |
| Teach a Man to Hospital... | Cure 1000 Patients |  |
| Dr Know | Train a World-Class Researcher | |
| Jung at Heart | Train a World-Class Psychiatrist | |
| Cut Above | Train a World-Class Surgeon | |
| Well-Informed | Complete 50 Research Projects | |
| Always Be Curing | Run 50 Marketing Campaigns | |
| Bells & Whistles | Conduct 25 Machine Upgrades | |
| I. See. You. | Capture 100 Ghosts | |
| County-Wide | Earn 15 Gold Stars | |
| Inter-Countinental | Earn 30 Gold Stars | |
| Pointy Mountain G.O.A.T | Earn 45 Gold Stars | |
| JUMBO | Reach $50,000,000 Organisation Value |  |
| Two Point Bounty | Earn 10,000 Kudosh | |
| Double Digits | Have a Level 10 Hospital | |
| Double Double | Have a Level 20 Hospital | |
| I'd Like To Thank My Mother | Win every award in a single hospital | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| High Altitude Health Service | Earn 1 Star at each hospital in the Pointy Mountains | |
| The New Gold Standard | Earn 54 Gold Stars | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| The (Second) New Gold Standard | Earn 63 Gold Stars | |
| Busman's Holiday | Earn 1 Star at each hospital on Pebberley Island | |
| Life, the Universe and Everything | Complete Wave 42 on Topless Mountain | |
| Symbiosis | Unlock every plot in Overgrowth | |