| Name | Description | |
| Total Radness | Unlock all Rad Trophies |  |
| Mender Contender | Participate in a Daily Challenge |  |
| Cool Customer | Upgrade Shermie's Shop | |
| Shopaholic | Upgrade Shermie's Shop to the max! |  |
| Tapes Never Sleep | Become a Platinum member | |
| Greed Is Good | Become a Desert Chrome member | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Money Shot | Eject 100 tapes from an ATM | |
| Drupe Ninja | Heal, burn and heal some more using fruit | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Noob No More | Unlock 25% of the Tome of the Ancients | |
| Book Worm | Unlock 50% of the Tome of the Ancients | |
| Brainiac | Unlock 75% of the Tome of the Ancients | |
| Nerd! | Unlock 100% of the Tome of the Ancients |  |
| Two-bular! | Discover a Mutation Combo | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Hidden Trophy | Continue playing to unlock this trophy. | |
| Fallout Collection | Unlock all styles | |
| Maul Rat | Unlock all weapons | |
| Quirk Berzerk | Unlock all Quirks | |
| Doin' a Solid | Do someone a solid | |
| Greenish Thumb | Help Billy farm a plant | |
| Green Machine | Help Billy complete his garden | |
| Honorary Disciple | Complete Cathode Raider Tasks | |
| Commune Contributor | Complete Transfigured Tasks | |
| Optimal Coroutine | Complete Vestigial Tasks | |
| Cool Runnings | Fully upgrade the town statue | |
| Total Annihilation! | Annihilate 5 enemies at once | |
| Killer! | Get a Kill Streak of 10 or more | |
| Cluuuuutch! | Get a Survivor Streak of 10 or more | |
| Mender Bartender | Receive a tasty beverage from the Mender altar | |
| Mender Tender | Receive a cash payout from the Mender altar | |
| Mender Offender | Receive disapproval from the Mender altar | |
| Colossal Blunder | Shamefully fall to your death while fighting the Colossus | |
| I Am Bat Man | Complete the game De-Made style | |
| Total Bummer | Load your body up with the bummer mutation trifecta | |
| Halo Effect | Capitalize on your bodaciousness | |
| Flappy Nerd | Stay aloft for 10 seconds | |