Full list of all 80 The Binding of Isaac: Rebirth trophies - 69 bronze, 5 silver, 5 gold and 1 platinum.
The base game contains 59 trophies, and there are 3 DLC packs containing 21 trophies.
Obtain all trophies
100% the game
Collect all items and unlock all secrets and endings
Kill Isaac with The Lost
Beat all 20 Challenges
Kill Satan with The Lost
Kill Satan with ???
Beat the Depths/Necropolis without taking damage
Finish the game's final secret
Beat the Womb/Utero without taking damage
Kill Isaac with Azazel
Kill Satan with Azazel
Kill Isaac with Eve
Kill Satan with Eve
Kill Satan with Samson
Kill Satan with Eden
Beat the Chest or Dark Room without taking damage
Beat the Dark Room
Beat the Dark Room with Isaac
You are the best!
Kill Satan with Judas
Beat Sheol 5 times
Beat the Caves/Catacombs without taking damage
Kill Satan with Isaac
Kill Isaac with Lazarus
Beat the Chest
Kill Isaac with Eden
Kill Isaac with Samson
Beat Cathedral 5 times
Kill Satan with Cain
Kill Satan with Maggy
Kill Isaac with Judas
Kill Isaac with Maggy
Kill Isaac with Cain
Kill Mom using the Bible
Kill Mom's Heart 11 times
Kill Satan
Kill Satan with Lazarus
Kill Mom's Heart 10 times
Kill Mom's Heart 9 times
Beat the Depths 20 times
Kill Isaac with Isaac
Kill Mom's Heart 8 times
Beat the Caves 30 times
Kill Mom's Heart 5 times
Beat the Boss Rush
Beat 2 levels in a row without taking damage
Beat the Basement/Cellar without taking damage
Kill all 7 sins
Beat the Basement 40 times
Hold 55 or more pennies at one time
Kill Mom's Heart 3 times
Beat the Womb for the first time
Make 3 deals with the devil in one run
Kill Mom
Have 7 or more max red hearts at one time
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball
Beat 2 levels in a row without picking up any hearts
Have 4 or more soul hearts at one time
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Kill Delirium with Apollyon
Beat Greedier Mode with Apollyon
Complete all hard mode marks with Apollyon
Kill Hush for the first time
Kill Delirium for the first time
Beat 3 victory laps in one run
Just Stop!
Complete ??? 3 times
Beat Hard mode as Lazarus without losing a life
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character
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